刘正芬，理学博士，副教授，硕士生导师。云南省“兴滇英才支持计划”青年人才；曲靖市第四届青年联合会常委；曲靖市“珠源百人计划”教育人才；教育部首批高校“百名研究生党员标兵”。从事有机合成方法学的研究工作，主要进行C—H键的官能团化研究，针对药物活性分子中比较具有挑战性的碳—碳键及碳—杂键进行构建。主持国家自然科学基金项目1项；主持云南省“兴滇英才支持计划”青年人才项目1项；主持云南省科技厅面上项目1项；主持云南省科技厅青年项目1项。在《Coordination Chemistry Reviews》《Chemical Science》《Journal of Catalysis》《Organic Letters》等学术刊物发表论文20余篇。申请发明专利10余项，授权3项。指导学生获第十八届“挑战杯”全国大学生课外学术科技作品竞赛获国家级三等奖1项；立项国家级大学生创新创业项目2项，其余各类赛事获省级奖项12项。承担《有机化学》《制药工程学》《制药工艺学及计算机仿真》等本科生专业课的教学任务。
一、发表论文
(1) Xiaobo Li, Jianghui Chen, Shiyu Shen, Changshuai Zhang, Chenyi Bu, Zhengfen Liu*, Jian-Jun Liu*. Naphthalenediimide-based donor–acceptor COFs with low exciton binding energy toward sunlight-driven synthesis of multisubstituted olefins and sulfoxides. Journal of Materials Chemistry A, 2026, 14(6): 3520-3533.
(2) Junli Yang, Dongdong Sun, Xingbo Guo, Ziwei Hu, Qiandie Yang, Mengling Lang, Le Chen, Zhengfen Liu*, Xianchen Hu*. Concentration- and cucurbit[n]urils-regulated molecular packing modes for constructing continuously red-shifted multi-stimuli responsive luminescent system, Dyes and Pigments, 2026, 247, 113456.
(3) Zhengfen Liu, Xiaobo Li, Weijun Dai, Jian-Jun Liu*, Mei-Jin Lin*. Naphthalenediimide and perylenediimide based donor-acceptor crystalline hybrid materials: Structures and applications. Coordination Chemistry Reviews, 2025, 526, 216350.
(4) Hongjiu Liang, Junyan Wang, Lingtao Kong, Yuyan Shuai, Jianghui Chen, Xiaobo Li, Zhengfen Liu*, and Jian-Jun Liu*. Perylenediimide-Based Donor–Acceptor MOF for Sunlight-Driven Photocatalytic N-α-C(sp3)–H Bond Functionalization of Tetrahydroisoquinoline. Inorganic Chemistry, 2025, 64(37): 19014-19025.
(5) Xiaobo Li, Jiajie Zhou, Wenxiu Yin, Baozhen Xie, Zhengfen Liu*, Jian-Jun Liu*. Fully conjugated radical-doped COF for near-infrared photothermal conversion, C-3 thiocyanation of indoles and oxidative coupling of amines. Journal of Catalysis, 2024, 437, 115640.
(6) Zhengfen Liu, Chao Li, Jian Chen, Xiaobo Li, Fumang Luo, Feixiang Cheng* and Jian-Jun Liu*. Photoactive perylenediimide metal–organic framework for boosting iodoperfluoroalkylation of alkenes and oxidative coupling of amines. Inorganic Chemistry Frontiers, 2022, 9(1): 111-118.
(7) Zhengfen Liu, Xiaobo Li, Wenxiu Yin, Jian Chen, Chao Li, Feixiang Cheng*, Jian-Jun Liu*. Perylenediimide-based hybrid materials for the iodoperfluoroalkylation of alkenes and oxidative coupling of amines: bay-substituent-mediated photocatalytic activity. ACS Applied Materials & Interfaces, 2022, 14(47): 53090-53100.
(8) Zhengfen Liu, Xiaobo Li, Jian Chen, Chao Li, Fumang Luo, Fei-Xiang Cheng* and Jian-Jun Liu*. Merging of the photocatalyst decatungstate and naphthalene diimide in a hybrid structure for the oxidative coupling of amine. Dalton Transactions, 2022, 51(21): 8472-8479.
(9) Zhengfen Liu, Yaguan Zhang, Jianwei Dong, Yongsheng Fang, Yonggang Jiang, Xiaodong Yang*, Feixiang Cheng*. Synthesis and antitumor activity of novel hybrid compounds between 1, 4‐benzodioxane and imidazolium salts. Archiv der Pharmazie, 2022, 355(10): 2200109.
(10) Linlin Zhang, Zhengfen Liu, Xun Tian, Yujin Zi, Shengzu Duan, Yongsheng Fang, Wen Chen, Hong Jing, Lijuan Yang*, and Xiaodong Yang*. Transition-metal-free C(sp3)–H coupling of cycloalkanes enabled by single-electron transfer and hydrogen atom transfer. Organic Letters, 2021, 23(5): 1714-1719.
(11) Zhengfen Liu‡, Minyan Li‡*, Guogang Deng, Wanshi Wei, Ping Feng, Quanxing Zi, Tiantian Li, Hongbin Zhang*, Xiaodong Yang* and Patrick J. Walsh*. Transition-metal-free C(sp3)–H/C(sp3)–H dehydrogenative coupling of saturated heterocycles with N-benzyl imines. Chemical Science, 2020, 11(29): 7619-7625.
(12) Zhengfen Liu†, Yonggang Jiang†, Chunxiang Liu†, Linlin Zhang, Jing Wang, Tiantian Li, Hongbin Zhang, Minyan Li,* and Xiaodong Yang*. Metal-Free Synthesis of Phenol-Aryl Selenides via Dehydrogenative C–Se Coupling of Aryl Selenoxides with Phenols. The Journal of Organic Chemistry, 2020, 85(11): 7386-7398.
(13) Liu, Zhengfen; Zi, Yujin; Zhang, Linlin; Li, Yan; Fang, Yongsheng; Shen, Yanzhen; Yang, Xiaodong*; Zhang, Hongbin*. Synthesis and Cytotoxic Activity of Novel Hybrid Compounds between Piperonyl and Imidazolium Salts. Chinese Journal of Organic Chemistry, 2020, 40(3): 669.
(14) Zhengfen Liu, Minyan Li, Bijun Wang, Guogang Deng, Wen Chen, Byeong-Seon Kim, Hongbin Zhang, Xiaodong Yang* and Patrick J. Walsh*. Chemoselective synthesis of aryl (pyridinyl) methanol derivatives through Ni-NIXANTPHOS catalyzed α-arylation and tandem arylation/rearrangement of pyridylmethyl ethers. Organic Chemistry Frontiers, 2018, 5(12): 1870-1876.
(15) Liu, Zhengfen; Zhang, Chaobo; Duan, Shengzu; Liu, Yang; Chen, Wen; Li, Yan ; Zhang, Hongbin*; Yang，Xiaodong*. Synthesis and Cytotoxic Activity of Novel Hybrid Compounds between lndolo[b]tetrahydrofuran and Imidazolium salts. Chinese Journal of Organic Chemistry, 2017, 37(06): 1506-1515.
二、主持项目
(1) 云南省“兴滇英才支持 计划”青年人才专项项目, 基于光介导的MOF材料催化杂环分子C－H键的官能团化研究, 2024-01至2028-12, 41万元, 在研, 主持
(2) 国家自然科学基金项目, 22261047, 基于光介导的苝酰亚胺/奎宁环协同催化实现饱和杂环烷烃C(sp3)－H键的官能团化研究, 2023-01-01至2026-12-31, 33万元, 在研, 主持
(3) 云南省科学技术厅基础研究专项—面上项目, 202201AT070013, 2-吡啶芳甲基—咪唑盐类化合物的 设计、合成及生物活性研究, 2022-06至 2025-05, 10万元, 结题, 主持
(4) 云南省科学技术厅基础研究专项—青年项目, 202101AU070004, 基于苯并六元杂环的咪唑盐类化合物 的合成及抗肿瘤活性研究, 2021-04至2024-03, 5万元, 结题, 主持
三、授权发明专利
(1) 刘正芬; 羊晓东; 成飞翔; 张鸭关; 一种喹啉—苯并咪唑盐类化合物及其合成方法和应用, 2022-12 27, 中国, ZL202111043017.1
(2) 刘正芬; 羊晓东; 成飞翔; 张鸭关; 一种1,4-苯并二噁烷-苯并咪唑盐类化合物及其合成方法和应用, 2024-04-09, 中国, ZL 2021 1 1001739.0
(3) 羊晓东; 刘正芬; 江永刚; 刘春祥; 张洪彬; 赵静峰; 陈文; 二芳基硒化物的合成方法, 2021-04-02, 中国, ZL201910692850.5
四、获奖和其他
(1) 2025年获曲靖师范学院教学创新大赛一等奖
(2) 2024年获云南省第一届高校青年教师教学大赛一等奖
(3) 2024年获曲靖师范学院“精彩一课”教学大赛特等奖
(4) 2024年获曲靖师范学院教学创新大赛一等奖
(5) 参与《有机化学》课程建设，2024年获云南省一流本科课程（排名第2）
(6) 2023年，指导学生获第十八届“挑战杯”全国大学生课外学术科技作品竞赛获国家级三等奖1项
(7) 2022及2025年，分别指导学生立项国家级大学生创新创业项目2项